DNA methylation
Base-resolution maps of 5mC and 5hmC across tissues, ages, and exposures.
Bisulfite · Enzymatic · Long-read
A research consortium of the American Southwest
The Southwest Epigenetics Consortium unites labs across six states to map the epigenome — the chemical layer that decides which genes speak, when, and why.
Why a consortium
So we pool the hard parts. Instruments, data, and expertise are shared across the network, and every result flows back into a common, open record.
Pooled sequencing and methylation cores, bookable across every member institution at cost.
One portal for Southwest epigenome data — harmonized, versioned, citable, and open by default.
Standardized protocols, hands-on workshops, and fellowships for the next generation of scientists.
Research areas
From the chemistry of a single cytosine to environmental exposures unique to the arid Southwest.
Base-resolution maps of 5mC and 5hmC across tissues, ages, and exposures.
ATAC, ChIP, and CUT&RUN profiling of the regulatory landscape.
Resolving cell-type-specific regulation, one nucleus at a time.
How heat, aridity, dust, and altitude leave marks on Southwestern populations.
Methylation signatures for early detection, subtyping, and minimal residual disease.
Shared pipelines, clocks, and models — reproducible from raw reads to figures.
The Southwest Epigenome Atlas
A federated portal spanning member datasets — methylation, accessibility, and expression aligned to a common reference, ready to browse, query, or bulk-download.
Resources & learning
Protocols, standards, and training — written by the network, kept current, free to use.
Vetted, versioned bench protocols for methylation and chromatin assays.
Metadata schemas and QC thresholds that keep the atlas comparable.
Monthly methods seminars and the annual Southwest Epigenetics Meeting.
Funded early-career fellowships and cross-lab rotations across the network.
Member institutions
+ 6 affiliated centers · See the full membership
News & events
Forty new snmC-seq datasets spanning brain, blood, and lung are now live and citable.
Read release notesConsortium-wide study links chronic heat exposure to durable changes at stress-response loci.
View the paperThree days in Albuquerque: methods workshops, keynotes, and the fellowship showcase.
RegisterMembership
Institutions, core facilities, and individual labs across the Southwest are welcome. Members share infrastructure, contribute to the atlas, and shape where the field goes next.